Researchers demonstrated an imaging strategy called scanning electrochemical microscopy been demonstrated as a powerful tool to create highly resolved images of the distributions of relevant biomolecules in cells and tissues without suffering from the optical interference of conventional microscopy. Instead of using additional chemicals like dyes or fluorescent markers for better visualization of tissue, this method uses soft electrochemical probes to identify natural biomolecules surrounding the tissue.
In this analysis, the research workers used very soft microelectrodes that were brushed carefully across tissue samples. While it migrated across them, it measured the electric current produced by certain chemicals in the tissue to get an idea of the physical framework of that tissue as well as its composition. The team provided three separate demonstrations of this technique’s use.
Initially, it scanned mouse livers to show a certain kind of nanoribbon that’s being examined as a potential drug delivery device can be sent out throughout the liver. In the next, the probes measured hemoglobin proteins to obtain a full image of a mouse heart(showed in image b). And in third test, the researchers used the technique to show that this can accurately identify healthy human muscle from cancerous muscle.
In the future, the researchers would like to use this solution to not only find cancerous cells but also destroy them. “We are perfectly capable of using soft electrochemical probes to destroy cancer cells on microscope slides and in petri plates,” Hubert Girault, and writer of the study, said in a statement, “but doing this in thick structure is another report.”